Chemical constituents and antioxidant activity of Garcinia Parvifolia Miq. stem bark

Muhammad Aizam Hassan, Norazah Basar, Farediah Ahmad


The chemical constituents of GarciniaparvifoliaMiq.stem bark have been studied. The dried samples have been extracted using Soxhlet apparatus to give the crude products. The constituents were separated and purified by using vacuum column chromatography, gravity column chromatography and recrystallisation. The chemical compounds obtained were elucidated by infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. Two compounds namely as 1,6,7-trihydroxy-3-methoxyxanthone and 3,8''-binaringenin were isolated from the ethyl acetate crude extracts of G. parvifoliaMiq. The free-radical scavenging activity of the crude extracts were determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The ethyl acetate extract was found to be the most active free radical scavenger with IC50 value of 4.2 ppm, followed by methanol extract (IC50 96 ppm) and petroleum ether extract (IC50 200 ppm).

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