Synthesis and characterization of polyethylene glycol-coated mesoporous maghemite nanoparticles as carriers of anticancer therapeutics in inhalational delivery sSystems

A. Dabbagh, N.H. Abu Kasim, C.H. Yeong, T.W. Wong


The iron oxide nanoparticles with superparamagnetic characteristics are potential carriers for utilization in pulmonary drug delivery systems. However, their low surface area leads to insufficient loading capacity for encapsulation or conjugation of diagnostic and therapeutic agents. In this study, we have synthesized maghemite nanoparticles with mesoporous structure using cetyl trimethyl ammonium bromide (CTAB) as template. The synthesized nanoparticles were then coated with a thin layer of polyethylene glycol with molecular weight of 1500 Da (PEG1500) in order to endow thermosensitive characteristics to the nanoparticles and protect their cargo from uncontrolled release. The results showed that although incorporation of CTAB to the synthesis solution led to a significant increase of particle size, however the surface area was also increased from 29 ± 8 to 91 ± 17 m2.g-1, indicating the improved capability of nanoparticles for loading and attachment of different diagnostic and therapeutic compounds. Moreover, the onset phase transition temperature of the protective PEG1500 at 40.4 ± 1.8°C makes these nanoparticles appropriate for application under hyperthermia condition.


Maghemite; Surface Area; Hyperthermia; lung cancer; pulmonary delivery

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