Aerosolized nanoemulsion system encapsulating quercertin for lung cancer treatment

N.H. Arbain N.H. Arbain, C.L. Ngan, N. Salim, W.T. Wui, M.B. Abdul Rahman


Formulation of aerosol nanoemulsion containing quercetin was carried out using low and high energy homogenizers. The effects of oils (1.0%–4.0% wt%), lecithin (1.0-2.0 wt%) and Tween 80 (0.5–1 wt%) on the droplet size of quercetin nanoemulsions were investigated. The optimum formulation for preparation of quercetin nanoemulsions having the desirable criteria was 1.0 % of oils, 2.0 % of lecithin and 1.0 % of Tween 80 and 95.95 % of aqueous phase. Under optimum formulation, the droplet size was 112.5 nm. Volume median diameter of nanoemulsion in this study was 4.991± 0.008 μm, Span value was 1.662 ± 0.029 and fine particle fraction (% FPF < 5.14 μm) was 55.19 ± 0.153. These results suggest that nanoemulsion -based palm oil in this study could be successful nanocarrier of quercetin as pulmonary delivery system for lung cancer treatment.


Aerosol; nanoemulsions; quercetin; lung cancer; pulmonary delivery

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